Rare disorders have many faces: in silico characterization of rare disorder spectrum

被引:0
作者
Simona D. Frederiksen
Vladimir Avramović
Tatiana Maroilley
Anna Lehman
Laura Arbour
Maja Tarailo-Graovac
机构
[1] University of Calgary,Departments of Biochemistry, Molecular Biology and Medical Genetics, Cumming School of Medicine
[2] University of Calgary,Alberta Children’s Hospital Research Institute
[3] University of British Columbia,Department of Medical Genetics
来源
Orphanet Journal of Rare Diseases | / 17卷
关键词
Borderline-common; Diagnostics; Pipelines; Developmental defect; Neurological; Causative genes; Phenotypes; Pathway analysis; Orphanet;
D O I
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[1]  
Fernandez-Marmiesse A(2018)NGS technologies as a turning point in rare disease research Diagnosis Treat Curr Med Chem 25 404-432
[2]  
Gouveia S(2018)Rare genetic diseases: update on diagnosis, treatment and online resources Drug Discov Today 23 187-195
[3]  
Couce ML(2016)Diagnostic odyssey in severe neurodevelopmental disorders: toward clinical whole-exome sequencing as a first-line diagnostic test Clin Genet 89 700-707
[4]  
Pogue RE(2018)Paediatric genomics: diagnosing rare disease in children Nat Rev Genet 19 253-268
[5]  
Cavalcanti DP(2017)Resequencing at scale in neurodevelopmental disorders Nat Genet 49 488-489
[6]  
Shanker S(2014)Genome sequencing identifies major causes of severe intellectual disability Nature 511 344-347
[7]  
Andrade RV(2005)Diagnostic error in internal medicine Arch Intern Med 165 1493-1499
[8]  
Aguiar LR(2002)Reducing diagnostic errors in medicine: what’s the goal? Acad Med 77 981-992
[9]  
de Carvalho JL(1980)The van der Woude syndrome in a large kindred: variability, penetrance, genetic risks Am J Med Genet 5 117-123
[10]  
Thevenon J(2013)Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease Hum Genet 132 1077-1130