Protein kinase C isozymes and addiction

被引：0
作者：
M. Foster Olive
Robert O. Messing
机构：
[1] University of California at San Francisco,Ernest Gallo Clinic and Research Center, Department of Neurology
来源：
Molecular Neurobiology | 2004年 / 29卷
关键词：
Protein kinase C; isozymes; ethanol; cocaine; amphetamine; opiates; knockout mouse;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Protein kinase C (PKC) has long been recognized an important family of enzymes that regulate numerous aspects of neuronal signal transduction, neurotransmitter synthesis, release and reuptake, receptor and ion channel function, neuronal excitability, development, and gene expression. Much evidence has implicated PKCs in the effects of several drugs of abuse, and in behavioral responses to these drugs. The present review summarizes the effects of both acute and chronic exposure to various drugs of abuse on individual PKC isozymes in the brain. In addition, we summarize recent studies utilizing mice with targeted deletions of the genes for PKCγ and PKCɛ. These studies suggest that individual PKC isozymes play a role in the development of drug dependence and addiction.
引用
收藏
页码：139 / 153
页数：14
相关论文
共 377 条
[91]  
Messing R. O.(2001)Animal models in the study of protein kinase C isozymes J. Neurosci. 21 1-5
[92]  
Gerstin E. H.(2001)Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of γ-aminobutyrate type A receptors Pharmacol. Biochem. Behav. 69 99-110
[93]  
McMahon T.(2000)Ethanol differentially enhances hippocampal GABA Behav. Genet. 30 111-121
[94]  
Dadgar J.(1999) receptor-mediated responses in protein kinase Cγ (PKCγ) and PKCɛ null mice Nature Neurosci. 2 997-1002
[95]  
Messing R. O.(1999)Decreased ethanol sensitivity and tolerance development in γ-protein kinase C null mutant mice is dependent on genetic background Neuron 24 253-260
[96]  
Pandey S. C.(2002)Background genotype modulates the effects of γ-PKC on the development of rapid tolerance to ethanol-induced hypothermia J. Neurosci. 22 9905-9911
[97]  
Dwivedi Y.(2000)Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Eur. J. Neurosci. 12 4131-4140
[98]  
Piano M. R.(1999)Low level of response to alcohol as a predictor of future alcoholism Alcohol Alcohol. 34 231-243
[99]  
Schwertz D. W.(2001)Alcohol sensitivity and dependence Neuroscience 103 171-179
[100]  
Davis J. M.(2002)Genetic differences in tolerance and sensitization to the sedative/hypnotic effects of alcohol J. Clin. Invest. 110 1003-1010
567891011121314