Assessment of autonomic dysfunction with the COMPASS-31 and its relationship with disease activity and cardiovascular risks in patients with psoriatic arthritis

被引:0
|
作者
Halise Hande Gezer
Didem Erdem Gürsoy
Sevtap Acer Kasman
Mehmet Tuncay Duruöz
机构
[1] Ümraniye Training and Research Hospital,Department of Rheumatology
[2] Prof. Dr. Cemil Taşçıoğlu City Hospital,Department of Rheumatology
[3] Kartal Lütfi Kirdar City Hospital,Department of Rheumatology
[4] Marmara University School of Medicine,Division of Rheumatology, Department of Physical Medicine and Rehabilitation
来源
Rheumatology International | 2022年 / 42卷
关键词
Psoriatic arthritis; Autonomic dysfunction; Cardiovascular disease; Metabolic syndrome; COMPASS-31;
D O I
暂无
中图分类号
学科分类号
摘要
This study aimed to evaluate the autonomic dysfunction as assessed by the Composite Autonomic Symptom Score-31 (COMPASS-31) as well as its relationship with disease activity and cardiovascular risks in patients with psoriatic arthritis (PsA). This cross-sectional observational study involved 118 PsA patients (85 females, mean age 45.6 years) and 64 healthy subjects. Cardiovascular risks were recorded including body mass index (BMI), hypertension (HT), diabetes mellitus (DM), dyslipidemia, metabolic syndrome (MetS), and 10-year Framingham Risk scores (FRS) were calculated. PsA was assessed with regard to disease activity, quality of life, and function. Autonomic dysfunction was evaluated using the COMPASS-31 consisting of six subdivisions including orthostatic, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor functions. The mean disease duration was 63.3 months. The mean total COMPASS-31 score was significantly higher in PsA patients than in controls (24.4 vs 11.1; p < 0.001), as were all sub-domain scores. COMPASS-31 scores were significantly lower in patients with DAPSA-REM and MDA. The COMPASS-31 total score showed significant correlations with scores of pain, global assessment, fatigue, function, quality of life, DAPSA, and BASDAI (p < 0.05).The presence of HT, dyslipidemia, MetS, and abdominal obesity did not significantly affect the total COMPASS-31 and sub-domain scores, except for the secretomotor scores being significantly higher in patients with abdominal obesity and MetS (p < 0.05). COMPASS-31 scores were not significantly different across the FRS risk groups. The symptoms of autonomic dysfunction are prevalent in PsA patients. High disease activity and pain have negative effects on autonomic function, and also functional impairment, fatigue, and poor quality of life are associated with autonomic dysfunction. However, the COMPASS-31 was found to be insufficient to demonstrate a clear relationship between autonomic dysfunction and cardiovascular risk.
引用
收藏
页码:1539 / 1548
页数:9
相关论文
共 50 条
  • [21] IS SKIN DISEASE MORE IMPORTANT TO PATIENTS OR PHYSICIANS IN THE ASSESSMENT OF DISEASE ACTIVITY IN PSORIATIC ARTHRITIS?
    Sholter, D.
    Rahman, P.
    Avina-Zubieta, J. A.
    Kelsall, J.
    Arendse, R.
    Khraishi, M.
    Shaikh, S.
    Bensen, W. G.
    Rampakakis, E.
    Sampalis, J. S.
    Nantel, F.
    Shawi, M.
    Otawa, S.
    Lehman, A. J.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2014, 32 (05) : 807 - 807
  • [22] SERUM IRISIN LEVEL IN RHEUMATOID ARTHRITIS PATIENTS: ITS RELATIONSHIP TO DISEASE ACTIVITY AND CARDIOVASCULAR MANIFESTATIONS
    Soliman, S.
    Gad, R.
    Senosy, T.
    Higazi, A.
    Elshereef, R.
    ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 612 - 612
  • [23] IS SKIN DISEASE MORE IMPORTANT TO PATIENTS OR PHYSICIANS IN THE ASSESSMENT OF DISEASE ACTIVITY IN PSORIATIC ARTHRITIS?
    Sholter, D.
    Rahman, P.
    Avina-Zubieta, J. A.
    Kelsall, J.
    Arendse, R.
    Khraishi, M.
    Shaikh, S.
    Bensen, W. G.
    Rampakakis, E.
    Sampalis, J. S.
    Nantel, F.
    Shawi, M.
    Otawa, S.
    Lehman, A. J.
    ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 : 334 - 334
  • [24] Endothelial dysfunction in psoriatic arthritis patients: correlations between insulin resistance and disease activity
    Babalic, F. C. A.
    Borza, C.
    Rosca, C. ilie
    Gurban, C. V.
    Banciu, C. D.
    Mederle, O. A.
    Popa, M. D.
    Chelu, S. C.
    Marius, P.
    Sharma, A.
    Kundnani, N. R.
    Caraba, A. E.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2022, 26 (18) : 6796 - 6804
  • [25] Endothelial dysfunction in psoriatic arthritis patients: relation to serum uric acid and disease activity
    Heba M. Ragab
    Mervat A. Elsergany
    Rania Y. Mehanna
    Amira M. Ibrahim
    The Egyptian Journal of Internal Medicine, 37 (1)
  • [26] Metabolic syndrome and its relationship with the achievement of minimal disease activity state in psoriatic arthritis patients: an observational study
    Costa, Luisa
    Caso, Francesco
    Ramonda, Roberta
    Del Puente, Antonio
    Cantarini, Luca
    Darda, Md Abud
    Caso, Paolo
    Lorenzin, Mariagrazia
    Fiocco, Ugo
    Punzi, Leonardo
    Scarpa, Raffaele
    IMMUNOLOGIC RESEARCH, 2015, 61 (1-2) : 147 - 153
  • [27] SLEEP quality in patients with psoriatic arthritis and its relationship with disease activity and comorbidities: a cross-sectional study
    Esther Toledano
    Cristina Hidalgo
    Luis Gómez-Lechón
    Marta ibáñez
    Carolina Cristina Chacón
    Javier Martín-Vallejo
    Sonia Pastor
    Carlos Montilla
    Scientific Reports, 13
  • [28] Metabolic syndrome and its relationship with the achievement of minimal disease activity state in psoriatic arthritis patients: an observational study
    Luisa Costa
    Francesco Caso
    Roberta Ramonda
    Antonio Del Puente
    Luca Cantarini
    Md Abud Darda
    Paolo Caso
    Mariagrazia Lorenzin
    Ugo Fiocco
    Leonardo Punzi
    Raffaele Scarpa
    Immunologic Research, 2015, 61 : 147 - 153
  • [29] SLEEP quality in patients with psoriatic arthritis and its relationship with disease activity and comorbidities: a cross-sectional study
    Toledano, Esther
    Hidalgo, Cristina
    Gomez-Lechon, Luis
    Ibanez, Marta
    Chacon, Carolina Cristina
    Martin-Vallejo, Javier
    Pastor, Sonia
    Montilla, Carlos
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [30] Assessment of Crystals in the Synovial Fluid of Psoriatic Arthritis Patients in Relation to Disease Activity
    Geneva-Popova, Mariela
    Popova-Belova, Stanislava
    Popova, Velicka
    Stoilov, Nikolay
    DIAGNOSTICS, 2022, 12 (05)