Age-Dependent Changes in Calretinin Immunoreactivity and its Protein Level in the Gerbil Hippocampus

被引：0
作者：
Choong Hyun Lee
In Koo Hwang
Jung Hoon Choi
Ki-Yeon Yoo
Ok Kyu Park
Sung-Oh Huh
Yun Lyul Lee
Hyung-Cheul Shin
Moo-Ho Won
机构：
[1] Hallym University,Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine
[2] Seoul National University,Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science
[3] Hallym University,Department of Pharmacology, College of Medicine
[4] Hallym University,Department of Physiology, College of Medicine
[5] Hallym University,Institute of Natural Medicine
来源：
Neurochemical Research | 2010年 / 35卷
关键词：
Aging; Calretinin; CA regions; Dentate gyrus; Gerbil; Hippocampus;
D O I：
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中图分类号：
学科分类号：
摘要：
Calretinin (CR)-immunoreactive interneurons are well known as the interneuron specific interneurons in the hippocampus. CR-immunoreactive neurons form cellular network and regulate the activity of other GABAergic inhibitory interneurons in the hippocampus. In the present study, we investigated age-related changes in CR-immunoreactive neurons and protein levels in the gerbil hippocampus during normal aging. In all subregions of the gerbil hippocampus, the number of CR-immunoreactive neurons was significantly decreased in the postnatal month 6 (PM 6) group compared to that in the PM 1 group. Thereafter, CR-immunoreactive neurons were decreased with age. In addition, the number of CR-immunoreactive cells in the subgranular zone were significantly decreased in the PM 6 group. We also observed that CR protein levels were decreased gradually with age. These results indicate that both CR immunoreactivity and its protein level were decreased with age in the gerbil hippocampus during normal aging.
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页码：122 / 129
页数：7
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