Thirty Years of Clinical Experience with Carbamazepine in the Treatment of Bipolar IllnessPrinciples and Practice

被引：0
作者：
Robert M. Post
Terence A. Ketter
Thomas Uhde
James C. Ballenger
机构：
[1] Bipolar Collaborative Network,Department of Psychiatry and Behavioral Sciences
[2] Penn State School of Medicine,Department of Psychiatry
[3] Stanford University School of Medicine,Department of Psychiatry
[4] Penn State Milton S. Hershey Medical Center,undefined
[5] Medical University of South Carolina,undefined
来源：
CNS Drugs | 2007年 / 21卷
关键词：
Bipolar Disorder; Carbamazepine; Valproic Acid; Lamotrigine; Oxcarbazepine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Carbamazepine began to be studied in a systematic fashion in the 1970s and became more widely used in the treatment of bipolar disorder in the 1980s. Interest in carbamazepine has been renewed by (i) the recent US FDA approval of a long-acting preparation for the treatment of acute mania; (ii) studies suggesting some efficacy in bipolar depression; and (iii) evidence of prophylactic efficacy in some difficult-to-treat subtypes of bipolar illness. A series of double-blind controlled studies of the drug were conducted at the US National Institute of Mental Health from the mid-1970s to the mid-1990s. This review summarises our experience in the context of the current literature on the clinical efficacy, adverse effects and pharmacokinetic interactions of carbamazepine.
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页码：47 / 71
页数：24
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