Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

被引：0

作者：

Konstantinos J. Mavrakis

Andrew L. Wolfe

Elisa Oricchio

Teresa Palomero

Kim de Keersmaecker

Katherine McJunkin

Johannes Zuber

Taneisha James

Aly A. Khan

Christina S. Leslie

Joel S. Parker

Patrick J. Paddison

Wayne Tam

Adolfo Ferrando

Hans-Guido Wendel

机构：

[1] Cancer Biology & Genetics Program,Department of Pathology

[2] Memorial Sloan-Kettering Cancer Center,Department of Pathology and Laboratory Medicine

[3] Weill Cornell Graduate School of Medical Science,undefined

[4] Columbia University,undefined

[5] Institute for Cancer Genetics,undefined

[6] Columbia University,undefined

[7] Cold Spring Harbor Laboratory,undefined

[8] Cold Spring Harbor,undefined

[9] Watson School of Biological Sciences,undefined

[10] Cold Spring Harbor Laboratory,undefined

[11] Cold Spring Harbor,undefined

[12] Computational Biology,undefined

[13] Memorial Sloan-Kettering Cancer Center,undefined

[14] Expression Analysis Inc.,undefined

[15] Fred Hutchinson Cancer Research Center,undefined

[16] Joan and Sanford I. Weill Medical College of Cornell University,undefined

[17] Present address: Department of Gene and Cell Medicine & Black Family Stem Cell Institute,undefined

[18] Mount Sinai School of Medicine,undefined

[19] New York,undefined

[20] New York 10029,undefined

[21] USA.,undefined

来源：

Nature Cell Biology | 2010年 / 12卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

The 17–92 miRNA cluster promotes tumourigenesis although the identity of the specific miRNA responsible for this effect has been unclear. MiR-19 is sufficient to promote Notch induced T-cell associated leukaemia in vivo and a shRNA screen for genes that phenocopy miR-19 effects identifies PI3-K regulators as miR-19 target genes.

引用

页码：372 / 379

页数：7

共 25 条

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