Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway

被引:0
作者
P Pandey
P Seshacharyulu
S Das
S Rachagani
M P Ponnusamy
Y Yan
S L Johansson
K Datta
M Fong Lin
S K Batra
机构
[1] University of Nebraska Medical Center,Department of Biochemistry and Molecular Biology
[2] Eppley Institute for Research in Cancer and Allied Diseases,Department of Pathology and Microbiology
[3] University of Nebraska Medical Center,undefined
[4] College of Medicine,undefined
[5] University of Nebraska Medical Center,undefined
来源
British Journal of Cancer | 2013年 / 108卷
关键词
protein phosphatase type 2A; phosphorylation; dephosphorylation; AKT signalling; prostate cancer; PP2A subunits;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2590 / 2600
页数:10
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  • [51] Kokontis JM(2008)Cancer statistics, 2012 Cancer Lett 259 28-271
  • [52] Hiipakka RA(2001)Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells Oncogene 20 1152-659
  • [53] Fukuchi J(1992)Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells J Natl Cancer Inst 84 951-36036
  • [54] Lin HP(2003)Metastatic model for human prostate cancer using orthotopic implantation in nude mice Int J Oncol 23 1263-545
  • [55] Lin CY(2000)Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells Gut 47 268-287
  • [56] Huo C(2004)Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers Oncol Rep 11 655-29
  • [57] Su LC(2005)PPP2R1B gene alterations inhibit interaction of PP2A-Abeta and PP2A-C proteins in colorectal cancers J Biol Chem 280 36029-160
  • [58] Cohen P(2009)Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt Mol Cell 33 537-1251
  • [59] Esplin ED(1998)From promiscuity to precision: protein phosphatases get a makeover Science 282 284-666
  • [60] Ramos P(1995)Alterations of the PPP2R1B gene in human lung and colon cancer Biochem J 311 17-5578