Usefulness of esophagogastroduodenoscopy and 18F-fluorodeoxyglucose positron-emission tomography in detecting synchronous multiple primary cancers with oral cancer

被引：7

作者：

Ishibashi-Kanno N. ^{[1
]}

Yamagata K. ^{[1
]}

Uchida F. ^{[1
]}

Hasegawa S. ^{[1
,2
]}

Yanagawa T. ^{[1
]}

Bukawa H. ^{[1
]}

机构：

[1] Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki

[2] Department of Oral and Maxillofacial Surgery, Toyokawa City Hospital, Yawata-cho noji 23, Toyokawa

来源：

Oral and Maxillofacial Surgery | 2017年 / 21卷 / 4期

基金：

日本学术振兴会;

关键词：

!sup]18[!/sup]F-fluorodeoxyglucose; Multiple primary cancers; Oral cancer; PET-CT; Synchronous;

D O I：

10.1007/s10006-017-0644-z

中图分类号：

学科分类号：

摘要：

Purpose: The purpose of this study is to compare the value of screening for synchronous multiple primary cancers in other organs by esophagogastroduodenoscopy (EGD) or 18F-fluorodeoxyglucose positron-emission tomography (PET-CT) in patients newly diagnosed with oral cancer. Methods: We retrospectively examined consecutive Japanese patients who were diagnosed with oral squamous cell carcinoma (OSCC) and were screened for synchronous multiple primary cancers in other organs by EGD and/or PET-CT between January 2010 and December 2015 at our institution. The study included 190 patients (106 males and 84 females) from 36 to 93 years of age (median age 68.8 years). The patients were screened by EGD, PET-CT, or both before beginning treatment for OSCC. Results: Of 190 Japanese patients with OSCC, 15 had multiple primary cancers: 13 patients had double cancer and two had triple cancers. The sites of the 17 multiple primary cancers were gastric (6), esophageal (4), and lung (3), and ovarian, colon, liver, and thyroid (1 each). All of the gastric and esophageal cancers were found by EGD and were not detected by PET-CT. For three patients, the detection of multiple cancers affected the treatment modality or order of treatment selected for the OSCC. In two cases, the oral cancer and multiple primary cancer(s) in another organ were resected simultaneously by joint surgical teams. Conclusions: PET-CT for oral cancer patients is an effective supporting diagnostic tool. However, the ability of PET-CT has some limitations. Especially for early detection of the upper gastrointestinal cancers, it is necessary to be supplemented by EGD. © 2017, Springer-Verlag GmbH Germany.

引用

页码：391 / 396

页数：5

共 22 条

[1]

Crosher R., McIlroy R., The incidence of other primary tumours in patients with oral cancer in Scotland, Br J Oral Maxillofac Surg, 36, 1, pp. 58-62, (1998)

[2]

Fukuzawa K., Noguchi Y., Yoshikawa T., Saito A., Doi C., Makino T., Takanashi Y., Ito T., Tsuburaya A., High incidence of synchronous cancer of the oral cavity and the upper gastrointestinal tract, Cancer Lett, 144, 2, pp. 145-151, (1999)

[3]

Xu G.Z., Guan D.J., He Z.Y., (18)FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis, Oral Oncol, 47, 7, pp. 560-565, (2011)

[4]

Senft A., Hoekstra O.S., Witte B.I., Leemans C.R., de Bree R., Screening for distant metastases in head and neck cancer patients using FDG-PET and chest CT: validation of an algorithm, Eur Arch Oto-rhino-laryngology: Off J Eur Fed Oto-Rhino-Laryngological Soc, 273, 9, pp. 2643-2650, (2016)

[5]

Stokkel M.P., Terhaard C.H., Hordijk G.J., van Rijk P.P., The detection of local recurrent head and neck cancer with fluorine-18 fluorodeoxyglucose dual-head positron emission tomography, Eur J Nucl Med, 26, 7, pp. 767-773, (1999)

[6]

Lapela M., Eigtved A., Jyrkkio S., Grenman R., Kurki T., Lindholm P., Nuutinen J., Sutinen E., Solin O., Bjornskov I., Bretlau P., Friberg L., Holm S., Jensen M., Sand Hansen H., Minn H., Experience in qualitative and quantitative FDG PET in follow-up of patients with suspected recurrence from head and neck cancer, Eur J Cancer, 36, 7, pp. 858-867, (2000)

[7]

Krabbe C.A., Pruim J., Dijkstra P.U., Balink H., van der Laan B.F., de Visscher J.G., Roodenburg J.L., 18F-FDG PET as a routine posttreatment surveillance tool in oral and oropharyngeal squamous cell carcinoma: a prospective study, J Nucl Med: Off Publ, Soc Nucl Med, 50, 12, pp. 1940-1947, (2009)

[8]

Uyl-de Groot C.A., Senft A., de Bree R., Leemans C.R., Hoekstra O.S., Chest CT and whole-body 18F-FDG PET are cost-effective in screening for distant metastases in head and neck cancer patients, J Nucl Med: Off Publ Soc Nucl Med, 51, 2, pp. 176-182, (2010)

[9]

Charvat H., Sasazuki S., Inoue M., Iwasaki M., Sawada N., Shimazu T., Yamaji T., Tsugane S., Group J.S., Prediction of the 10-year probability of gastric cancer occurrence in the Japanese population: the JPHC study cohort II, Int J Cancer, 138, 2, pp. 320-331, (2016)

[10]

Shimada H., Okazumi S., Koyama M., Murakami K., Japanese gastric cancer association task force for research promotion: clinical utility of (1)(8)F-fluoro-2-deoxyglucose positron emission tomography in gastric cancer. A systematic review of the literature, Gastric Cancer, 14, 1, pp. 13-21, (2011)

← 1 2 3 →