BOLD fMRI response to direct stimulation (transcranial magnetic stimulation) of the motor cortex shows no decline with age

被引：0

作者：

K. A. McConnell

D. E. Bohning

Z. Nahas

A. Shastri

C. Teneback

J. P. Lorberbaum

M. P. Lomarev

D. J. Vincent

M. S. George

机构：

[1] Departments of Radiology,

[2] ,undefined

[3] Psychiatry,undefined

[4] and,undefined

[5] Neurology,undefined

[6] Center for Advanced Imaging Research and the Brain Stimulation Laboratory,undefined

[7] Medical University of South Carolina,undefined

[8] and,undefined

[9] Ralph H. Johnson Veterans Hospital,undefined

[10] Charleston,undefined

[11] SC,undefined

[12] U.S.A.,undefined

来源：

Journal of Neural Transmission | 2003年 / 110卷

关键词：

Keywords: Transcranial magnetic stimulation; motor cortex; fMRI; blood flow; imaging; aging.;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Previous studies using BOLD fMRI to examine age-related changes in cortical activation used tasks that relied on peripheral systems to activate the brain. They were unable to distinguish between alterations due to age-related changes in the periphery and actual changes in cortical physiology. Transcranial magnetic stimulation (TMS), which allows direct, noninvasive stimulation of cortical neurons, was interleaved with BOLD fMRI to study 6 young and 5 old subjects. Three different tasks were compared: direct stimulation by TMS, indirect active stimulation produced by a motor task, and indirect passive stimulation produced by hearing the TMS coil discharge.

引用

页码：495 / 507

页数：12