Botulinum neurotoxin B–host receptor recognition: it takes two receptors to tango

被引：0
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作者：
Michael R Baldwin
Jung-Ja P Kim
Joseph T Barbieri
机构：
[1] Medical College of Wisconsin,the Department of Microbiology and Molecular Genetics and Jung
来源：
Nature Structural & Molecular Biology | 2007年 / 14卷
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摘要：
Two independent crystal structure analyses have resolved the detailed interactions between botulinum neurotoxin serotype B and its neuronal receptor, synaptotagmin. The studies show how the toxin binds synaptotagmin and, along with previously determined interactions with the ganglioside GT1b, a coreceptor, explain the toxin's extreme toxicity and tropism for neurons.
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页码：9 / 10
页数：1
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