Primary amelanotic mucosal melanoma of the oronasal region: report of two new cases and literature review

被引：11
作者：
de Paulo L.F.B. [1 ,2 ]
Servato J.P.S. [1 ]
Rosa R.R. [1 ]
Oliveira M.T.F. [2 ]
de Faria P.R. [4 ]
da Silva S.J. [3 ]
Cardoso S.V. [1 ]
Loyola A.M. [1 ]
机构：
[1] Oral Pathology Area, School of Dentistry, Federal University of Uberlândia, Uberlândia
[2] Oral and Maxillofacial Surgery Department, Clinical Hospital, Federal University of Uberlândia, Uberlândia
[3] Head and Neck Surgery Department, Clinical Hospital, Federal University of Uberlândia, Uberlândia
[4] Department of Morphology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG
来源：
Oral and Maxillofacial Surgery | 2015年 / 19卷 / 4期
关键词：
Amelanotic mucosal melanomas; Malignant melanomas; Nasal cavity; Oral cavity;
D O I：
10.1007/s10006-015-0501-x
中图分类号：
学科分类号：
摘要：
Primary amelanotic mucosal melanoma is a rare entity with challenging histopathological features. Because these tumors are thought to be biologically more aggressive, they have a poorer prognosis than that of pigmented melanomas. In this work, we present a literature review about the clinical, histopathological, and immunohistochemical features of primary amelanotic mucosal melanoma of the oronasal region and report two new cases. Amelanotic mucosal melanoma commonly affects men in the seventh decade of life and tend to have a poor prognosis, as seen by the high incidence of metastasis, recurrences, and, ultimately, death. There is a similar pattern in the clinic-pathological predilections (such as age, gender, primary site, and metastatic potential) of amelanotic mucosal melanoma when comparing with data reported for pigmented lesions. This work reinforces knowledge about amelanotic mucosal melanomas and epidemiologic predilections. The optimal management of this lesion remains controversial. © 2015, Springer-Verlag Berlin Heidelberg.
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页码：333 / 339
页数：6
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