Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity

被引：0
作者：
Parvaneh Pakravan
Soheila Kashanian
Mohammad M. Khodaei
Frances J. Harding
机构：
[1] Islamic Azad University,Department of Chemistry, Zanjan Branch
[2] Razi University,Department of Chemistry, Sensor and Biosensor Research Center (SBRC) & Nanoscience and Nanotechnology Research Center (NNRC), Faculty of Science
[3] University of South Australia,Mawson Institute
来源：
Pharmacological Reports | 2013年 / 65卷 / 2期
关键词：
isatin; derivatives; DNA and HSA binding; antimicrobial; anticancer; anticonvulsant; antioxidant;
D O I：
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中图分类号：
学科分类号：
摘要：
Isatin, k1H-indole-2,3-dione, kis a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule, ka precursor for a large number of pharmacologically active compounds. Isatin and its derivatives have aroused great attention in recent years due to their wide variety of biological activities, krelevant to application as insecticides and fungicides and in a broad range of drug therapies, kincluding anticancer drugs, kantibiotics and antidepressants. The purpose of this review is to provide an overview of the pharmacological activities of isatin and its synthetic and natural derivatives. Molecular modifications to tailor the properties of isatin and its derivatives are also discussed.
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页码：313 / 335
页数：22
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