Integrating oncolytic viruses in combination cancer immunotherapy

被引：536

作者：

Bommareddy, Praveen K. ^{[1
]}

Shettigar, Megha ^{[2
]}

Kaufman, Howard L. ^{[3
,4
]}

机构：

[1] Rutgers Grad Sch Biomed Sci, New Brunswick, NJ USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Replimune Inc, Woburn, MA USA

[4] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2018年 / 18卷 / 08期

关键词：

HERPES-SIMPLEX-VIRUS; IMMUNE CHECKPOINT BLOCKADE; NEWCASTLE-DISEASE VIRUS; T-CELL INFILTRATION; MHC CLASS-I; DENDRITIC CELLS; PROSTATE-CANCER; TALIMOGENE LAHERPAREPVEC; REPLICATING ADENOVIRUS; COMBINED NIVOLUMAB;

D O I：

10.1038/s41577-018-0014-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer-immunity cycle. Oncolytic viruses directly lyse tumour cells, leading to the release of soluble antigens, danger signals and type I interferons, which drive antitumour immunity. In addition, some oncolytic viruses can be engineered to express therapeutic genes or can functionally alter tumour-associated endothelial cells, further enhancing T cell recruitment into immune-excluded or immune-deserted tumour microenvironments. Oncolytic viruses can also utilize established tumours as an in situ source of neoantigen vaccination through cross-presentation, resulting in regression of distant, uninfected tumours. These features make oncolytic viruses attractive agents for combination strategies to optimize cancer immunotherapy.

引用

页码：498 / 513

页数：16

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