Electrophysiological Effects of a Single Intravenous Administration of Ivabradine (S 16257) in Adult Patients with Normal Baseline Electrophysiology

被引：131
作者：
A. John Camm
Chu-Pak Lau
机构：
[1] St George’s Hospital,The Medical School
[2] Queen Mary Hospital,undefined
来源：
Drugs in R & D | 2003年 / 4卷 / 2期
关键词：
Catheter Ablation; Refractory Period; Ivabradine; Reduce Heart Rate; Radiofrequency Catheter Ablation;
D O I：
10.2165/00126839-200304020-00001
中图分类号：
学科分类号：
摘要：
Introduction: Ivabradine is a heart rate-lowering agent that selectively inhibits the pacemaker current, If, in the sinoatrial node. The objective of this study was to evaluate the effects of a single intravenous administration of ivabradine on cardiac electrophysiological parameters in patients with normal baseline electrophysiology. The safety profile of ivabradine was also investigated.
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页码：83 / 89
页数：6
相关论文
共 52 条
[1]  
Kannel WB(1987)Heart rate and cardiovascular mortality: The Framingham Study Am Heart J 113 1489-94
[2]  
Kannel C(1990)Influence of heart rate on mortality after acute myocardial infarction Am J Cardiol 1 547-53
[3]  
Paffenbarger RS(1999)Heart rate as a therapeutic target in heart failure Eur Heart J 1 H64-9
[4]  
Hjalmarson E(1997)Management of stable angina pectoris: recommendations of the Task Force of the European Society of Cardiology Eur Heart J 18 394-413
[5]  
Gilpin J(1998)Beta-blocker treatment in heart failure: role of heart rate reduction Basic Res Cardiol 93 148-55
[6]  
Kjekshus J(1995)Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs J Pharmacol Exp Ther 275 659-66
[7]  
Kjekshus L(1999)Heart rate as a therapeutic target in hypertension Eur Heart J 1 H70-5
[8]  
Gullestad P(1999)Heart rate as a therapeutic target in ischaemic heart disease Eur Heart J 1 H58-63
[9]  
Lechat L(2000)Induction of insulin resistance by beta-blockade but not ACE-inhibition: longterm treatment with atenolol or trandolapril J Hum Hypertens 14 175-80
[10]  
Simon B(1994)Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49 Br J Pharmacol 112 37-42
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