The role of human papillomavirus in squamous carcinoma of the head and neck

被引：33
作者：
Li G. [1 ]
Sturgis E.M. [1 ]
机构：
[1] Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030
来源：
Current Oncology Reports | 2006年 / 8卷 / 2期
关键词：
Oral Cavity; Laryngeal Cancer; Neck Squamous Cell Carcinoma; Squamous Carcinoma; Oropharyngeal Cancer;
D O I：
10.1007/s11912-006-0048-y
中图分类号：
学科分类号：
摘要：
Human papillomavirus type-16 infection is associated with a significant portion of squamous carcinoma of the head and neck, particularly for the oropharynx and for those lacking the other risk factors of tobacco and alcohol. The link between human papillomavirus type-16 and carcinoma of the orpharynx is based on the identification of human papillomavirus type-16 in oropharyngeal tumors and the association of human papillomavirus type-16 with the risk of oropharyngeal cancer estimated in case-control epidemiologic studies. This review highlights the molecular mechanism of human papillomavirus carcinogenesis and the association of human papillomavirus type-16 as a risk factor for squamous cell carcinoma of the oropharynx as well as recent research efforts utilizing human papillomavirus as a biomarker of clinical outcomes. © 2006 by Current Science Inc.
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页码：130 / 139
页数：9
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