The initiation of liver development is dependent on Foxa transcription factors

被引：0
|
作者：
Catherine S. Lee
Joshua R. Friedman
James T. Fulmer
Klaus H. Kaestner
机构：
[1] Department of Genetics,Department of Pediatrics
[2] University of Pennsylvania School of Medicine,undefined
来源：
Nature | 2005年 / 435卷
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摘要：
Foxa1 and Foxa2 regulatory proteins have been identified as essential for the specification of the cells that form the liver in the vertebrate embryo. Mouse embryos lacking these proteins are essentially liver-less, with no liver bud in the foregut endoderm. The Foxa genetic system may prove to be a useful model for the study of the molecular control of organogenesis in general, since as well as the liver, this part of the embryo forms the lungs, thyroid and pancreas.
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页码：944 / 947
页数：3
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