HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

被引：0

作者：

Angela M Sosin

Angelika M Burger

Aisha Siddiqi

Judith Abrams

Ramzi M Mohammad

Ayad M Al-Katib

机构：

[1] Barbara Ann Karmanos Cancer Institute (KCI),Department of Oncology

[2] Wayne State University School of Medicine (WSU-SOM),Department of Pharmacology

[3] Biostatistics Core Facility (KCI),Department of Internal Medicine, Hematology

[4] WSU-SOM and the Lymphoma Clinic,Oncology

[5] Van Elslander Cancer Center,Division of Hematology and Oncology Department of Internal Medicine

[6] St John Hospital and Medical Center,undefined

[7] Wayne State University School of Medicine,undefined

来源：

Journal of Hematology & Oncology | / 5卷

关键词：

HDM2; p53; Apoptosis; MI-219; Nutlin-3; B-cell lymphoma; Small-molecule inhibitor; Autoubiquitination;

D O I：

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摘要：

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