Nonspecific effect of Na+/K+-ATPase inhibition with strophanthin or under hypothermia in rat heart

被引：0
作者：
Pogorelova V.N. [1 ]
Panait A.I. [1 ]
Pogorelov A.G. [1 ]
机构：
[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region
来源：
Biophysics | 2014年 / 59卷 / 5期
基金：
俄罗斯基础研究基金会;
关键词：
cardiac myocell; electron probe microanalysis; hypothermia; ischemia; Na[!sup]+[!/sup]/K[!sup]+[!/sup]-ATPase; strophanthin;
D O I：
10.1134/S0006350914050212
中图分类号：
学科分类号：
摘要：
Electron probe microanalysis was applied to study the kinetics of changes in potassium and sodium concentration in muscle cells of isolated heart from Wistar rat during experimental ischemia. Hypoxic perfusion without glucose was shown to evoke the potassium deficiency and sodium accumulation in cardiac myocells. Short-term action (10 min) of strophanthin (0.1 mM/L) recovered Na/K balance in ischemic myocells. Hypothermic perfusion exhibited the opportunity to conserve the cytoplasmic elemental contents in the state corresponding to the beginning of low temperature (4°C) operation. © 2014, Pleiades Publishing, Inc.
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收藏
页码：768 / 771
页数：3
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