Is type 2 diabetes mellitus an inverse risk factor for the development of rheumatoid arthritis?

被引：0
作者：
Jun Inamo
Yuta Kochi
Tsutomu Takeuchi
机构：
[1] Keio University School of Medicine,Division of Rheumatology, Department of Internal Medicine
[2] Tokyo Medical and Dental University,Department of Genomic Function and Diversity, Medical Research Institute
来源：
Journal of Human Genetics | 2021年 / 66卷
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摘要：
Type 2 diabetes mellitus (T2DM) and rheumatoid arthritis (RA) are both chronic diseases. Although the link between metabolic abnormalities and dysregulated inflammation has received much attention, it is not known whether T2DM can be a risk for the development of RA. Also, observational studies have the disadvantage that the possibility of confounding factors, such as environmental factors, cannot be ruled out. Therefore, the current study performed the mendelian randomization (MR) analysis using recent large-scale genome-wide association studies datasets of T2DM and RA separately European and Asian ancestries. As a result, T2DM had an inverse causal effect on the risk of RA. This study proposed a novel hypothesis that a protective effect of T2DM for the risk of RA.
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页码：219 / 223
页数：4
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共 101 条
[1]  
Stumvoll M(2005)Type 2 diabetes: principles of pathogenesis and therapy Lancet 365 1333-7
[2]  
Goldstein BJ(2010)Risk of diabetes among patients with rheumatoid arthritis, psoriatic arthritis and psoriasis Ann Rheum Dis 69 2114-52
[3]  
van Haeften TW(2014)Diabetes incidence in psoriatic arthritis, psoriasis and rheumatoid arthritis: a UK population-based cohort study Rheumatology 53 346-22
[4]  
Solomon DH(2014)Risk of rheumatoid arthritis in patients with type 2 diabetes: a nationwide population-based case-control study PLoS One 9 e101528-5
[5]  
Love TJ(2003)‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32 1-13
[6]  
Canning C(2020)Identification of type 2 diabetes loci in 433,540 East Asian individuals Nature 582 240-81
[7]  
Schneeweiss S(2018)Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps Nat Genet 50 1505-50
[8]  
Dubreuil M(2014)Genetics of rheumatoid arthritis contributes to biology and drug discovery Nature 506 376-400
[9]  
Rho YH(2018)Causal associations between risk factors and common diseases inferred from GWAS summary data Nat Commun 9 443-21
[10]  
Man A(1995)Problems with instrumental variables estimation when the correlation between the instruments and the endogenous explanatory variable is weak J Am Stat Assoc 90 1397-33
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