Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia

[1] Marcucci G(2012)Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia J Clin Oncol 30 742-50

[2] Metzeler KH(2010)DNMT3A mutations in acute myeloid leukemia N Engl J Med 363 2424-33

[3] Schwind S(2011)Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells J Exp Clin Cancer Res 30 98-73

[4] Becker H(2014)The mechanistic role of DNA methylation in myeloid leukemogenesis Leukemia 28 1765-60

[5] Maharry K(2013)DNA methyltransferases in hematologic malignancies Semin Hematol 50 48-96

[6] Mrozek K(2014)DNMT3A: the DioNysian MonsTer of acute myeloid leukaemia Ther Adv Hematol 5 187-51

[7] Ley TJ(2012)Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation J Biol Chem 287 30941-54

[8] Ding L(2014)The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers Cancer Cell 25 442-22

[9] Walter MJ(2012)Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies Semin Oncol 39 109-33

[10] McLellan MD(2014)Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia Nature 506 328-53

[1] Marcucci G(2012)Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia J Clin Oncol 30 742-50

[2] Metzeler KH(2010)DNMT3A mutations in acute myeloid leukemia N Engl J Med 363 2424-33

[3] Schwind S(2011)Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells J Exp Clin Cancer Res 30 98-73

[4] Becker H(2014)The mechanistic role of DNA methylation in myeloid leukemogenesis Leukemia 28 1765-60

[5] Maharry K(2013)DNA methyltransferases in hematologic malignancies Semin Hematol 50 48-96

[6] Mrozek K(2014)DNMT3A: the DioNysian MonsTer of acute myeloid leukaemia Ther Adv Hematol 5 187-51

[7] Ley TJ(2012)Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation J Biol Chem 287 30941-54

[8] Ding L(2014)The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers Cancer Cell 25 442-22

[9] Walter MJ(2012)Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies Semin Oncol 39 109-33

[10] McLellan MD(2014)Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia Nature 506 328-53