BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

被引:0
|
作者
Jeffrey A Kleim
Sheila Chan
Erin Pringle
Kellan Schallert
Vincent Procaccio
Richard Jimenez
Steven C Cramer
机构
[1] Brain Research Rehabilitation Center,Department of Neuroscience
[2] Malcom Randall VA Hospital,Departments of Neurology and Anatomy & Neurobiology
[3] Mcknight Brain Institute,Department of Pediatrics
[4] University of Florida,undefined
[5] PO Box 100244,undefined
[6] University of California Irvine Medical Center,undefined
[7] University of California Irvine,undefined
[8] 2034 Hewitt Hall,undefined
[9] Center for Molecular and Mitochondrial Medicine and Genetics,undefined
[10] University of California Irvine,undefined
[11] 2034 Hewitt Hall,undefined
来源
Nature Neuroscience | 2006年 / 9卷
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摘要
Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.
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页码:735 / 737
页数:2
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