BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

被引：0

作者：

Jeffrey A Kleim

Sheila Chan

Erin Pringle

Kellan Schallert

Vincent Procaccio

Richard Jimenez

Steven C Cramer

机构：

[1] Brain Research Rehabilitation Center,Department of Neuroscience

[2] Malcom Randall VA Hospital,Departments of Neurology and Anatomy & Neurobiology

[3] Mcknight Brain Institute,Department of Pediatrics

[4] University of Florida,undefined

[5] PO Box 100244,undefined

[6] University of California Irvine Medical Center,undefined

[7] University of California Irvine,undefined

[8] 2034 Hewitt Hall,undefined

[9] Center for Molecular and Mitochondrial Medicine and Genetics,undefined

[10] University of California Irvine,undefined

[11] 2034 Hewitt Hall,undefined

来源：

Nature Neuroscience | 2006年 / 9卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.

引用

页码：735 / 737

页数：2

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