Purinergic receptor: a crucial regulator of adipose tissue functions

被引：0
作者：
Dan Wang
Jianwei Zhou
机构：
[1] Chengdu University of Traditional Chinese Medicine,School of Acupuncture and Tuina
[2] Academy of Traditional Chinese Medicine Sciences,undefined
[3] Sichuan Province,undefined
来源：
Purinergic Signalling | 2023年 / 19卷
关键词：
Purinergic receptor; Adenosine; Obesity; Adipose tissue; Thermogenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Obesity is a public-health challenge resulting from an imbalance between energy expenditure and calorie intake. This health problem exacerbates a variety of metabolic complications worldwide. Adipose tissue is an essential regulator of energy homeostasis, and the functions within it are regulated by purinergic receptors. A1R, P2X7R, and P2YR mainly mediate energy homeostasis primarily through regulating energy storage and adipokines secretion in white adipose tissue (WAT). P2X5R is a novel-specific cell surface marker in brown/beige adipocytes. A2R is a promising therapeutic target for stimulating energy expenditure in brown adipose tissue (BAT) and also mediating WAT browning. Based on these features, purinergic receptors may be an appropriate target in treating obesity. In this review, the role of purinergic receptors in different types of adipose tissue is summarized. An improved understanding of purinergic receptor functions in adipose tissue may lead to more effective treatment interventions for obesity and its related metabolic disorders.
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页码：273 / 281
页数：8
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