Synthesis of 6-hydrazino-3,4-dimethyl-1H-pyrazolo[3,4-d]pyrimidine and its application for the construction of a pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidine system

被引：0

作者：

A. V. Komkov

A. S. Shashkov

S. V. Baranin

V. A. Dorokhov

机构：

[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry

来源：

Russian Chemical Bulletin | 2013年 / 62卷

关键词：

diacetyl ketene ; ,; -acetal; 5-acetyl-6-methyl-2,4-di(methylsulfanyl)pyrimidine; hydrazine; 6-hydrazino-1; -pyrazolo[3,4-; ]pyrimidine; amide acetals; aldehydes; condensation; oxidative cyclization; pyrazolo[4,3-; ][1,2,4]triazolo[4,3-; ]pyrimidines; 6-(1; -pyrazol-1-yl)-1; -pyrazolo[3,4-; ]pyrimidines;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A new representative of heterocyclic hydrazines, viz., 6-hydrazino-3,4-dimethyl-1H-pyrazolo[3,4-d]pyrimidine (3) was synthesized from diacetyl ketene N,S-acetal. A condensation of hydrazine 3 with amide acetals or aldehydes and subsequent cyclization furnished pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidines, whose structure was confirmed by 1H, 13C, and 1H/15N HMBC NMR spectroscopy. Reactions of hydrazine 3 with acetylacetone, ethyl acetoacetate, diethyl malonate, and acetic anhydride were studied.

引用

页码：1248 / 1254

页数：6

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