Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

被引：0
|
作者：
Bao Q Vuong
Mieun Lee
Shaheen Kabir
Cristina Irimia
Stephania Macchiarulo
G Stanley McKnight
Jayanta Chaudhuri
机构：
[1] Immunology Program,Department of Pharmacology
[2] Memorial Sloan-Kettering Cancer Center,undefined
[3] Gerstner Sloan-Kettering Graduate School of Biomedical Sciences,undefined
[4] University of Washington,undefined
来源：
Nature Immunology | 2009年 / 10卷
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学科分类号：
摘要：
Immunoglobulin class-switch recombination requires activation-induced cytidine deaminase. Chaudhuri and colleagues show independent recruitment of protein kinase A to switch regions, where it phosphorylates this deaminase to promote class-switch recombination.
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页码：420 / 426
页数：6
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