MART-1 Adenovirus-Transduced Dendritic Cell Immunization in a Murine Model of Metastatic Central Nervous System Tumor

被引：2
作者：
Howard Broder
Andrea Anderson
Thomas J. Kremen
Sylvia K. Odesa
Linda M. Liau
机构：
[1] University of California at Los Angeles School of Medicine,Division of Neurosurgery and the Jonsson Comprehensive Cancer Center
来源：
Journal of Neuro-Oncology | 2003年 / 64卷 / 1期
关键词：
brain tumor; dendritic cell; gene therapy; immunotherapy; melanoma; tumor immunity;
D O I：
10.1023/A:1024921506081
中图分类号：
学科分类号：
摘要：
Dendritic cells (DCs) are potent antigen-presenting cells that have been shown to play a critical role in the initiation of host immune responses against tumor antigens. In this study, a recombinant adenovirus vector encoding the melanoma-associated antigen, MART-1, was used to transduce murine DCs, which were then tested for their ability to activate cytotoxic T lymphocytes (CTLs) and induce protective immunity against B16 melanoma tumor cells implanted intracranially.
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页码：21 / 30
页数：9
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