NOD Mice Recapitulate the Cardiac Disturbances Observed in Type 1 Diabetes

被引：0

作者：

Ygor Schleier

Oscar Moreno-Loaiza

Maria Micaela López Alarcón

Eduarda Gabrielle Lopes Martins

Bruno Cabral Braga

Isalira Peroba Ramos

Antonio Galina

Emiliano Horacio Medei

机构：

[1] Federal University of Rio de Janeiro,Laboratory of Cardioimmunology, Institute of Biophysics Carlos Chagas Filho

[2] Federal University of Rio de Janeiro,Laboratory of Bioenergetics and Mitochondrial Physiology, Institute of Medical Biochemistry Leopoldo de Meis, Center for Health Sciences

[3] Federal University of Rio de Janeiro,National Center for Structural Biology and Bioimaging

[4] Carlos Chagas Filho Biophysics Institute – UFRJ,undefined

来源：

Journal of Cardiovascular Translational Research | 2021年 / 14卷

关键词：

Type 1 diabetes; Arrhythmias; Mitochondria; NOD mice; Electrophysiology;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This work aimed at testing the hypothesis that NOD/ShiLtJ mice (NOD) recapitulate the cardiac disturbances observed on type 1 diabetes (T1D). NOD mice were studied 4 weeks after the onset of hyperglycemia, and NOR/Lt mice matched as control. Cardiac function was evaluated by echocardiography and electrocardiography (ECG). Action potentials (AP) and Ca2+ transients were evaluated at whole heart level. Heart mitochondrial function was evaluated by high-resolution respirometry and H2O2 release. NOD mice presented a reduction in hearth weight. Mitochondrial oxygen fluxes and H2O2 release were similar between NOD and NOR mice. ECG revealed a QJ interval prolongation in NOD mice. Furthermore, AP duration at 30% of repolarization was increased, and it depicted slower Ca2+ transient kinetics. NOD mice presented greater number/severity of ventricular arrhythmias both in vivo and in vitro. In conclusion, NOD mice evoked cardiac electrical and calcium handling disturbances similar to the observed in T1D.

引用

页码：271 / 282

页数：11

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