Peritoneal morphology and function in long-term peritoneal dialysis

被引：0
作者：
Fußhöller A. [1 ,2 ]
Grabensee B. [1 ]
机构：
[1] Klinik für Nephrologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf
[2] Klinik für Nephrologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf
来源：
Der Nephrologe | 2007年 / 2卷 / 2期
关键词：
Encapsulating peritoneal sclerosis; Peritoneal dialysis; Peritoneal function; Peritoneal morphology; Ultrafiltration;
D O I：
10.1007/s11560-006-0064-9
中图分类号：
学科分类号：
摘要：
In chronic peritoneal dialysis (PD) uremia, relapsing peritonitis and the chronic influence of PD solutions often result in morphological and functional changes to the peritoneal membrane. Submesothelial fibrosis, angiogenesis and vasculopathy are typical peritoneal alterations. Glucose, glucose degradation products and advanced glycosylation end-products induce inflammation, fibrosis and angiogenesis, and lead clinically to an ultrafiltration failure due to an increased effective peritoneal surface area. This represents a major clinical problem. In addition, insufficient function of the water selective aquaporin 1 channel may be a cause of inadequate ultrafiltration. A rare but life threatening complication of long-term PD is encapsulating peritoneal sclerosis. Modern PD fluids, with less glucose degradation products, and initial pharmacological efforts may help to preserve the peritoneal membrane in the long-term. © 2007 Springer Medizin Verlag.
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页码：90 / 99
页数：9
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