COVID-19 and biomarkers of thrombosis: focus on von Willebrand factor and extracellular vesicles

被引:0
作者
Richard C. Becker
Travis Sexton
Susan Smyth
机构
[1] University of Cincinnati College of Medicine,Heart, Lung and Vascular Institute
[2] University of Kentucky,The Gill Heart and Vascular Institute
[3] University of Arkansas for Medical Sciences,undefined
来源
Journal of Thrombosis and Thrombolysis | 2021年 / 52卷
关键词
Thrombosis; Biomarkers; COVID-19; von Willebrand factor;
D O I
暂无
中图分类号
学科分类号
摘要
COVID-19, caused by the SARS-CoV-2 virus, is responsible for a pandemic of unparalleled portion over the past century. While the acute phase of infection causes significant morbidity and mortality, post-acute sequelae that can affect essentially any organ system is rapidly taking on an equally large part of the overall impact on human health, quality of life, attempts to return to normalcy and the global economy. Herein, we summarize the potential role of von Willebrand Factor and extracellular vesicles toward understanding the pathophysiology, clinical presentation, duration of illness, diagnostic approach and management of COVID-19 and its sequelae.
引用
收藏
页码:1010 / 1019
页数:9
相关论文
共 85 条
[1]  
Grobler C(2020)(2020) Covid-19: the rollercoaster of fibrin(ogen), D-dimer, Von Willebrand factor, P-selectin and their interactions with endothelial cells, platelets and erythrocytes Int J Mol Sci 21 5168-594
[2]  
Becker RC(2021)COVID-19 and its sequelae: a platform for optimal patient care, discovery and training J Thromb Thrombolysis 51 587-67
[3]  
Becker RC(2020)COVID-19 update: Covid-19-associated coagulopathy J Thromb Thrombolysis 50 54-9
[4]  
Ruggeri ZM(2000)Role of von Willebrand factor in platelet thrombus formation Ann Med 32 2-22
[5]  
Huisman B(2017)Modeling the cleavage of von Willebrand factor by ADAMTS13 protease in shear flow Med Eng Phys 48 14-424
[6]  
Sadler JE(1998)Biochemistry and genetics of von Willebrand factor Annu Rev Biochem 67 395-511
[7]  
Becker RC(2020)COVID-19-associated vasculitis and vasculopathy J Thromb Thrombolysis 50 499-627
[8]  
Wagner DD(1991)von Willebrand factor and the endothelium Mayo Clin Proc 66 621-2592
[9]  
Bonfanti R(2014)Control of VWF A2 domain stability and ADAMTS13 access to the scissile bond of full-length VWF Blood 123 2585-16
[10]  
Lynch CJ(2011)Von Willebrand disease: an overview Indian J Pharm Sci 73 7-114