Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

被引：0

作者：

Brett S Carver

Jennifer Tran

Anuradha Gopalan

Zhenbang Chen

Safa Shaikh

Arkaitz Carracedo

Andrea Alimonti

Caterina Nardella

Shohreh Varmeh

Peter T Scardino

Carlos Cordon-Cardo

William Gerald

Pier Paolo Pandolfi

机构：

[1] Cancer Biology and Genetics Program,Department of Surgery, Division of Urology

[2] Sloan-Kettering Institute,Department of Pathology

[3] Memorial Sloan-Kettering Cancer Center,Department of Medicine and Pathology

[4] Memorial Sloan-Kettering Cancer Center,Department of Pathology

[5] Memorial Sloan-Kettering Cancer Center,undefined

[6] Cancer Genetics Program,undefined

[7] Beth Israel Deaconess Cancer Center,undefined

[8] Harvard Medical School,undefined

[9] Columbia University,undefined

来源：

Nature Genetics | 2009年 / 41卷

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摘要：

Pier Paolo Pandolfi and colleagues report that prostate-specific overexpression of ERG in transgenic mice results in no overt phenotype on its own but promotes progression of intraepithelial neoplasia to adenocarcinoma in a PTEN heterozygous background. They also find that human TMPRSS2-ERG–positive tumors are enriched for PTEN loss, suggesting that these two events cooperate in human prostate tumorigenesis.

引用

页码：619 / 624

页数：5

共 42 条

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