The Pregnancy Exposome

被引：71

作者：

Robinson O. ^{[1
,2
,3
]}

Vrijheid M. ^{[1
,2
,3
]}

机构：

[1] Centre for Research in Environmental Epidemiology (CREAL), Barcelona

[2] Universitat Pompeu Fabra (UPF), Barcelona

[3] CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona

来源：

Current Environmental Health Reports | 2015年 / 2卷 / 2期

关键词：

Child health; Exposome; Exposure; Multi-pollutant; Omics; Pregnancy;

D O I：

10.1007/s40572-015-0043-2

中图分类号：

学科分类号：

摘要：

The exposome concept takes a holistic approach facilitated by new and emerging technologies to describe ‘the totality of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome’. It provides a framework to advance the environmental epidemiology field that has until now focused almost exclusively on single-exposure health effects. The exposome includes an external domain, measured by methods including geo-spatial modelling, questionnaire and biomonitoring of external exposures while the internal domain is commonly assessed through molecular omics platforms. The internal domain, in part, reflects the biological response to the external domain. New statistical frameworks are required to integrate and assess exposome-health effects. The pregnancy period is a key starting point to describe the dynamic exposome, due to its heightened sensitivity and potential lifetime impact. A handful of studies have started to move towards an exposome approach in assessing the effects of the multiple exposures during pregnancy on child development. New research projects are underway to test the exposome approach on a large scale. © 2015, Springer International Publishing AG.

引用

页码：204 / 213

页数：9

共 50 条

[1]

Wild C.P., Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology, Cancer Epidemiol Biomarkers Prev, 14, pp. 1847-1850, (2005)

[2]

Wild C.P., The exposome: from concept to utility, Int J Epidemiol, 41, pp. 24-32, (2012)

[3]

Vrijheid M., Slama R., Robinson O., Chatzi L., Coen M., van den Hazel P., Et al., The human early-life exposome (HELIX): project rationale and design, Environ Health Perspect, 122, pp. 535-544, (2014)

[4]

Wild C.P., Scalbert A., Herceg Z., Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk, Environ Mol Mutagen, 54, pp. 480-499, (2013)

[5]

Rappaport S.M., Barupal D.K., Wishart D., Vineis P., Scalbert A., The blood exposome and its role in discovering causes of disease, Environ Health Perspect, 122, pp. 769-774, (2014)

[6]

Miller G.W., Jones D.P., The nature of nurture: refining the definition of the exposome, Toxicol Sci, 137, pp. 1-2, (2014)

[7]

Peters A., Hoek G., Katsouyanni K., Understanding the link between environmental exposures and health: does the exposome promise too much?, J Epidemiol Community Health, 66, pp. 103-105, (2012)

[8]

Patel C.J., Bhattacharya J., Butte A.J., An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus, PLoS One, 5, (2010)

[9]

Nieuwenhuijsen M., Donaire-Gonzalez D., Foraster M., Martinez D., Cisneros A., Using personal sensors to assess the exposome and acute health effects, Int J Environ Res Public Health, 11, pp. 7805-7819, (2014)

[10]

Chadeau-Hyam M., Athersuch T.J., Keun H.C., De Iorio M., Ebbels T.M.D., Jenab M., Et al., Meeting-in-the-middle using metabolic profiling—a strategy for the identification of intermediate biomarkers in cohort studies, Biomarkers, 16, pp. 83-88, (2011)

← 1 2 3 4 5 →