Microwave-assisted solution combustion synthesis of high aspect ratio calcium phosphate nanoparticles

被引：0
作者：
Darcy E. Wagner
Joseph Lawrence
Sarit B. Bhaduri
机构：
[1] University of Toledo,Department of Biomedical Engineering, Colleges of Engineering and Medicine
[2] University of Toledo,Department of Bioengineering, College of Engineering
[3] University of Toledo,Department of Mechanical, Industrial, and Manufacturing Engineering, College of Engineering
[4] University of Toledo,Division of Dentistry, College of Medicine
[5] University of Vermont College of Medicine,Vermont Lung Center, Department of Pulmonary and Critical Care
来源：
Journal of Materials Research | 2013年 / 28卷
关键词：
microwave heating; combustion synthesis; nanoscale;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Calcium phosphates (CaPs) are major chemical constituents of mammalian bone. Their osteoconductivity in vitro and in vivo has encouraged their use in biomaterial applications such as implant materials and drug delivery. High aspect ratio nanoparticles are attractive for many biomedical applications; however, precise control of the phase and morphology is challenging. The impact of fuel-to-oxidant ratio, pH, and cation chemistry on morphology and phase was studied for CaP-based compositions by microwave-assisted solution combustion synthesis (MASCS) in a urea–nitrate (fuel–oxidant) system. An initial calcium to phosphate ratio of 1.5 was used. Highly crystalline hydroxyapatite (HA) and biphasic CaP nanoparticle compositions were produced as confirmed by x-ray diffraction, scanning electron microscopy, and transmission electron microscopy. MASCS was capable of synthesizing high aspect ratio (∼5 to 20) single and biphasic CaP nanoparticles with diameters ranging from 250 to 500 nm and lengths between 2 and 10 μm.
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页码：3119 / 3129
页数：10
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