Impact of N6-methyladenosine (m6A) modification on immunity

被引：0
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作者：
Raghda A. Elsabbagh
Mona Rady
Carsten Watzl
Khaled Abou-Aisha
Mohamed Z. Gad
机构：
[1] The German University in Cairo,Biochemistry Department, Faculty of Pharmacy and Biotechnology
[2] The German University in Cairo,Microbiology, Immunology and Biotechnology Department, Faculty of Pharmacy and Biotechnology
[3] German International University,Faculty of Biotechnology
[4] New Administrative Capital,Department of Immunology
[5] Leibniz Research Centre for Working Environment and Human Factors (IfADo)-TU Dortmund,undefined
来源：
Cell Communication and Signaling | / 20卷
关键词：
N6-methyl-adenosine; Innate; Adaptive; Immunity; m; A writers; m; A erasers; m; A readers;
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摘要：
N6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m6A modification has been implicated in various human diseases. Thus, m6A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m6A in regulating immune cell functions and immune responses.
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