Serum Cardiotrophin-1 and IL-6 Levels in Patients with Obstructive Sleep Apnea Syndrome

被引：0
作者：
Ozlem Kar Kurt
Mehmet Tosun
Fahrettin Talay
机构：
[1] Abant Izzet Baysal University,Department of Chest Diseases, Faculty of Medicine
[2] Abant Izzet Baysal University,Department of Biochemistry, Faculty of Medicine
来源：
Inflammation | 2013年 / 36卷
关键词：
cardiotrophin-1; interleukin-6; obstructive sleep apnea syndrome; inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Obstructive sleep apnea syndrome (OSAS) is associated with increased rates of cardiovascular diseases (CVD). Basic mechanisms involved in the increased cardiovascular risk of OSAS remain unclear. Inflammation has been shown to potentially play a critical role in this association. The aim of the present study was to investigate the level of cardiotrophin-1 (CT-1) in patients with OSAS. Forty-eight newly diagnosed OSAS patients and 37 nonapneic controls were enrolled in this study. Demographic data, cigarette smoking status, previous history of chronic diseases including CVD and metabolic diseases and drugs, and habits were obtained by a standardized questionnaire. All patients underwent polysomnographic evaluation. The mean age was 48.3 ± 12.3 (24–74) years in OSAS group. Median apnea–hypopnea index was 23.6 (6–91.8) and median body mass index was 30.4 (24.2–49.4) in the OSAS group. Plasma CT-1 levels in OSAS and control groups, respectively, were 12.03 ± 1.08 and 11.85 ± 1.18 pg/ml. There was no significant difference in the plasma levels of CT-1 and IL-6 between the OSAS group and the controls.
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页码：1344 / 1347
页数：3
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