Metformin-Loaded BSA Nanoparticles in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug

被引：0
作者：
Pinkybel Jose
K. Sundar
C. H. Anjali
Aswathy Ravindran
机构：
[1] SASTRA University,Center for Nanotechnology and Advanced Biomaterials (CeNTAB), School of Chemical and Biotechnology
来源：
Cell Biochemistry and Biophysics | 2015年 / 71卷
关键词：
BSA, MiaPaCa-2; Hyperglycemia; Hyperinsulinemia; Pancreatic cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Clinical and experimental data suggest that there is a strong association between type II diabetic mellitus and pancreatic cancer. The present study focuses on exploring the anticancer and antidiabetic properties of metformin-loaded bovine serum albumin nanoparticles (BSA NPs) on (MiaPaCa-2) pancreatic carcinoma cell lines. Albumin nanoparticles were synthesized using coacervation method and the average size of the particles was found to be 97 nm. The particles were stable and showed a spherical morphology with narrow size distribution. We investigated the impact of two stages characterized in type II diabetes mellitus (hyperglycemia and hyperinsulinemia) on the proliferation of MiaPaCa-2 cells and compared the inhibitory effects of bare metformin to that of MET-BSA NPs. Further, different concentrations of insulin and glucose were added along with bare metformin, bare BSA, and metformin encapsulated BSA carrier on MiaPaCa-2 cells to check the strong association between type II diabetes and pancreatic cancer. The results revealed that MET-BSA NPs showed more toxicity when compared with drug and carrier individually.
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页码：627 / 636
页数：9
相关论文
共 165 条
[1]  
Nie SM(2007)Nanotechnology applications in cancer Annual Review of Biomedical Engineering 9 257-288
[2]  
Xing Y(2006)Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems Nano Letters 6 2427-2430
[3]  
Kim GJ(2008)Nanoparticle-mediated cellular response is size-dependent Nature Nanotechnology 3 145-150
[4]  
Simons JW(2006)Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells Nano Letters 6 662-668
[5]  
Nasongkla N(2005)Nuclear delivery of macromolecules: barriers and carriers Advanced Drug Delivery Reviews 57 505-527
[6]  
Bey E(2006)Nanocarriers: Promising vehicle for bioactive drugs Bioogical & Pharmaceutical Bulletin 29 1790-1798
[7]  
Ren JM(1998)Host–guest encapsulation of materials by assembled virus protein cages Nature 393 152-155
[8]  
Ai H(2007)A virus-based single-enzyme nanoreactor Nature Nanotechnology 2 635-639
[9]  
Khemtong C(2003)Design strategies to improve soluble macromolecular delivery constructs Advanced Drug Delivery Reviews 55 421-437
[10]  
Guthi JS(2010)Subcellular targeting strategies for drug design and delivery Nature Reviews Drug Discovery 9 29-42
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