Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine

被引：0
|
作者：
Ralf Buettner
Le Xuan Truong Nguyen
Corey Morales
Min-Hsuan Chen
Xiwei Wu
Lisa S. Chen
Dinh Hoa Hoang
Servando Hernandez Vargas
Vinod Pullarkat
Varsha Gandhi
Guido Marcucci
Steven T. Rosen
机构：
[1] City of Hope Medical Center,Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research
[2] City of Hope Medical Center,Integrative Genomics Core, Beckman Research Institute
[3] The University of Texas MD Anderson Cancer Center,Department of Experimental Therapeutics
来源：
Journal of Hematology & Oncology | / 14卷
关键词：
Acute myeloid leukemia; Oxidative phosphorylation; Fatty acid oxidation; Nucleoside analog; Metabolism;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine
    Buettner, Ralf
    Nguyen, Le Xuan Truong
    Morales, Corey
    Chen, Min-Hsuan
    Wu, Xiwei
    Chen, Lisa S.
    Hoang, Dinh Hoa
    Hernandez Vargas, Servando
    Pullarkat, Vinod
    Gandhi, Varsha
    Marcucci, Guido
    Rosen, Steven T.
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)
  • [2] 8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia
    Buettner, Ralf
    Le Xuan Truong Nguyen
    Kumar, Bijender
    Morales, Corey
    Liu, Chao
    Chen, Lisa S.
    Pemovska, Tea
    Synold, Timothy W.
    Palmer, Joycelynne
    Thompson, Ryan
    Li, Ling
    Dinh Hoa Hoang
    Zhang, Bin
    Ghoda, Lucy
    Kowolik, Claudia
    Kontro, Mika
    Leitch, Calum
    Wennerberg, Krister
    Yu, Xiaochun
    Chen, Ching-Cheng
    Horne, David
    Gandhi, Varsha
    Pullarkat, Vinod
    Marcucci, Guido
    Rosen, Steven T.
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (09) : 16295 - 16303
  • [3] A phase 1 trial of 8-chloro-adenosine in relapsed/refractory acute myeloid leukemia: An evaluation of safety and pharmacokinetics
    Pullarkat, Vinod
    Chen, Lisa S.
    Palmer, Joycelynne
    Zhang, Jianying
    Synold, Timothy W.
    Buettner, Ralf
    Nguyen, Le Xuan Truong
    Marcucci, Guido
    Tsai, Ni-Chun
    Wang, Yan
    O'Hearn, James
    Gandhi, Varsha
    Rosen, Steven T.
    CANCER, 2024, 130 (05) : 727 - 739
  • [4] Synergy of Venetoclax and 8-Chloro-Adenosine in AML: The Interplay of rRNA Inhibition and Fatty Acid Metabolism
    Dinh Hoa Hoang
    Morales, Corey
    Rodriguez, Ivan Rodriguez
    Valerio, Melissa
    Guo, Jiamin
    Chen, Min-Hsuan
    Wu, Xiwei
    Horne, David
    Gandhi, Varsha
    Chen, Lisa S.
    Zhang, Bin
    Pullarkat, Vinod
    Rosen, Steven T.
    Marcucci, Guido
    Buettner, Ralf
    Nguyen, Le Xuan Truong
    CANCERS, 2022, 14 (06)
  • [5] Targeting Metabolic Reprogramming in Acute Myeloid Leukemia
    Castro, Isabel
    Sampaio-Marques, Belem
    Ludovico, Paula
    CELLS, 2019, 8 (09)
  • [6] Understanding and Targeting Metabolic Vulnerabilities in Acute Myeloid Leukemia: An Updated Comprehensive Review
    Addanki, Sridevi
    Kim, Lana
    Stevens, Alexandra
    CANCERS, 2025, 17 (08)
  • [7] Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia
    Chapuis, Nicolas
    Poulain, Laury
    Birsen, Rudy
    Tamburini, Jerome
    Bouscary, Didier
    FRONTIERS IN ONCOLOGY, 2019, 9
  • [8] Pharmacological targeting of β-catenin in normal karyotype acute myeloid leukemia blasts
    Griffiths, Elizabeth A.
    Golding, Michelle C.
    Srivastava, Pragya
    Povinelli, Benjamin J.
    James, Smitha R.
    Ford, Laurie A.
    Wetzler, Meir
    Wang, Eunice S.
    Nemeth, Michael J.
    HAEMATOLOGICA, 2015, 100 (02) : E49 - E52
  • [9] Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia
    Kawakatsu, Renshi
    Tadagaki, Kenjiro
    Yamasaki, Kenta
    Kuwahara, Yasumichi
    Yoshida, Tatsushi
    DISEASES, 2025, 13 (01)
  • [10] Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia
    Bosc, Claudie
    Saland, Estelle
    Bousard, Aurelie
    Gadaud, Noemie
    Sabatier, Marie
    Cognet, Guillaume
    Farge, Thomas
    Boet, Emeline
    Gotanegre, Mathilde
    Aroua, Nesrine
    Mouchel, Pierre-Luc
    Polley, Nathaniel
    Larrue, Clement
    Kaphan, Eleonore
    Picard, Muriel
    Sahal, Ambrine
    Jarrou, Latifa
    Tosolini, Marie
    Rambow, Florian
    Cabon, Florence
    Nicot, Nathalie
    Poillet-Perez, Laura
    Wang, Yujue
    Su, Xiaoyang
    Fovez, Quentin
    Kluza, Jerome
    Arguello, Rafael Jose
    Mazzotti, Celine
    Avet-Loiseau, Herve
    Vergez, Francois
    Tamburini, Jerome
    Fournie, Jean-Jacques
    Tiong, Ing S.
    Wei, Andrew H.
    Kaoma, Tony
    Marine, Jean-Christophe
    Recher, Christian
    Stuani, Lucille
    Joffre, Carine
    Sarry, Jean-Emmanuel
    NATURE CANCER, 2021, 2 (11) : 1204 - +
12345