Targeted modulation of immune cells and tissues using engineered biomaterials

被引：89

作者：

Yousefpour, Parisa ^{[1
]}

Ni, Kaiyuan ^{[1
]}

Irvine, Darrell J. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[3] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[4] MIT, Ragon Inst Massachusetts Gen Hosp, Cambridge, MA 02139 USA

[5] Harvard Univ, Cambridge, MA 02138 USA

[6] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

NATURE REVIEWS BIOENGINEERING | 2023年 / 1卷 / 02期

关键词：

CD8(+) T-CELLS; NEUTRALIZING ANTIBODY-RESPONSES; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; SOLID TUMORS; IN-VIVO; VASCULAR NORMALIZATION; NANOPARTICLE VACCINES; 1ST-IN-HUMAN PHASE-1; TRAINED IMMUNITY;

D O I：

10.1038/s44222-022-00016-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Therapies modulating the immune system offer the prospect of treating a wide range of conditions including infectious diseases, cancer and autoimmunity. Biomaterials can promote specific targeting of immune cell subsets in peripheral or lymphoid tissues and modulate the dosage, timing and location of stimulation, thereby improving the safety and efficacy of vaccines and immunotherapies. Here, we review recent advances in biomaterials-based strategies, focusing on targeting of lymphoid tissues, circulating leukocytes, tissue-resident immune cells and immune cells at disease sites. These approaches can improve the potency and efficacy of immunotherapies by promoting immunity or tolerance against different diseases.

引用

页码：107 / 124

页数：18

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