The Role of NRF2/KEAP1 Pathway in Glioblastoma: Pharmacological Implications

被引：0

作者：

Seyed Hossein Shahcheraghi

Fateme Salemi

Waqas Alam

Henry Ashworth

Luciano Saso

Haroon Khan

Marzieh Lotfi

机构：

[1] Shahid Sadoughi Hospital,Infectious Diseases Research Center

[2] Shahid Sadoughi University of Medical Sciences,Department of Medical Genetics, School of Medicine

[3] Shahid Sadoughi University of Medical Sciences,School of Medicine

[4] Islamic Azad University of Medical Sciences,Department of Pharmacy

[5] Abdul Wali Khan University Mardan,Department of Physiology and Pharmacology “Vittorio Erspamer”

[6] Harvard Medical School,Abortion Research Center

[7] Sapienza University,undefined

[8] Reproductive Sciences Institute,undefined

[9] Shahid Sadoughi University of Medical Sciences,undefined

来源：

Medical Oncology | / 39卷

关键词：

Glioblastoma multiforme; NF-E2-related factor 2; Kelch-like ECH-related protein 1; Therapeutic options;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Glioblastoma multiforme (GBM) grade IV glioma is the most frequent and deadly intracranial cancer. This tumor is determined by unrestrained progression, uncontroled angiogenesis, high infiltration and weak response to treatment, which is chiefly because of abnormal signaling pathways in the tumor. A member related to the Cap ‘n’ collar family of keypart-leucine zipper transcription agents—the transcription factor NF-E2-related factor 2 (Nrf2)-regulates adaptive protection answers by organized upregulation of many genes that produce the cytoprotective factors. In reply to cellular pressures types such as stresses, Nrf2 escapes Kelch-like ECH-related protein 1 (Keap1)-facilitated suppression, moves from the cytoplasm towards the nucleus and performs upregulation of gene expression of antioxidant responsive element (ARE). Nrf2 function is related tocontrolling many types of diseases in the human specially GBM tumor.Thus, we will review the epigeneticalregulatory actions on the Nrf2/Keap1 signaling pathway and potential therapeutic options in GBM by aiming the stimulation of Nrf2.

引用

共 386 条

[1]

Wirsching H-G(2016)Glioblastoma Handb Clin Neurol 134 381-397

[2]

Galanis E(2021)Therapeutic potential of marine peptides in glioblastoma: Mechanistic insights Cel Signal 87 110142-12

[3]

Weller M(2017)Aspects of carbon monoxide in form of CO-releasing molecules used in cancer treatment: more light on the way Oxid Med Cell Longev 2017 1-3278

[4]

Ahmed S(2011)Aberrant signaling pathways in glioma Cancers 3 3242-2710

[5]

Hasan MM(2007)Malignant astrocytic glioma: genetics, biology, and paths to treatment Genes Dev 21 2683-312

[6]

Aschner M(2020)Management of glioblastoma: State of the art and future directions CA A Cancer J Clin 70 299-584

[7]

Mirzaei H(2016)Nrf2 expressions correlate with WHO grades in gliomas and meningiomas Int J Mol Sci 17 722-e

[8]

Alam W(2014)Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α Int J Cancer 135 574-562

[9]

Shah SMM(2016)Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma Cell Death Dis 7 e2213-504

[10]

Kourti M(2020)6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance BioFactors 46 550-325

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