Statin use and cancer risk in the General Practice Research Database

被引：0
作者：
J A Kaye
H Jick
机构：
[1] Boston Collaborative Drug Surveillance Program,
[2] Boston University School of Medicine,undefined
来源：
British Journal of Cancer | 2004年 / 90卷
关键词：
3-hydroxy-3-methylglutaryl coenzyme A inhibitors; statins; hyperlipidaemia; epidemiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In a matched case–control study using the General Practice Research Database, current statin use was not associated with a significantly altered risk of any of 13 studied cancers. Untreated hyperlipidaemia was associated with slightly increased risks of colon cancer (relative risk 1.8; 95% confidence interval 1.2–2.8), prostate cancer (1.5; 1.1–2.0), and bladder cancer (1.9; 1.2–3.1).
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页码：635 / 637
页数：2
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[11]  
Bjerre LM(2000)The incidence of breast cancer in the General Practice Research Database compared with national cancer registration data Br J Cancer 83 1556-1558
[12]  
LeLorier J(2002)3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis Gastroenterology 122 308-317
[13]  
Blais L(1998)Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis Int J Oncol 12 717-723
[14]  
Desgagné A(1996)Carcinogenicity of lipid-lowering drugs JAMA 275 55-60
[15]  
LeLorier J(2002)3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA Circ Res 91 143-150
[16]  
Coogan PF(2002)Safety and tolerability of pravastatin in long-term clinical trials: prospective Pravastatin Pooling (PPP) Project Circulation 105 2341-2346
[17]  
Rosenberg L(1996)The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators N Engl J Med 335 1001-1009
[18]  
Palmer JR(2002)Statins have biphasic effects on angiogenesis Circulation 105 739-745
[19]  
Strom BL(2002)HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis Leukemia 16 508-519
[20]  
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