Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels

被引：0
|
作者：
Na Sun
Axel Walch
机构：
[1] Helmholtz Zentrum München,Research Unit Analytical Pathology, Institute of Pathology
[2] German Research Center for Environmental Health,undefined
来源：
Histochemistry and Cell Biology | 2013年 / 140卷
关键词：
Mass spectrometry imaging; Quantitation; Drug; Metabolite; In situ; High resolution;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mass spectrometry imaging (MSI) is a rapidly evolving technology that yields qualitative and quantitative distribution maps of small pharmaceutical-active molecules and their metabolites in tissue sections in situ. The simplicity, high sensitivity and ability to provide comprehensive spatial distribution maps of different classes of biomolecules make MSI a valuable tool to complement histopathology for diagnostics and biomarker discovery. In this review, qualitative and quantitative MSI of drugs and metabolites in tissue at therapeutic levels are discussed and the impact of this technique in drug discovery and clinical research is highlighted.
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页码：93 / 104
页数：11
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