Bone biopsy in patients with osteoporosis

被引：0

作者：

Malluche H.H. ^{[1
]}

Mawad H. ^{[1
]}

Monier-Faugere M.-C. ^{[1
]}

机构：

[1] Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky Medical Center, Lexington, KY 40536

来源：

Current Osteoporosis Reports | 2007年 / 5卷 / 4期

关键词：

Osteoporosis; Bone Turnover; Alendronate; Teriparatide; Ibandronate;

D O I：

10.1007/s11914-007-0009-x

中图分类号：

学科分类号：

摘要：

Although rarely used to diagnose and manage patients with osteoporosis, bone biopsies are performed to establish bone quality, including degree of mineralization and microarchitecture; to assess bone turnover and bone loss mechanisms; and to analyze treatment effects on bone structure and bone turnover. Bone biopsies are also the only method to diagnose mineralization defect or frank osteomalacia. Due to the availability of antiresorptive agents and anabolic drugs, determining bone turnover and bone-loss mechanisms is critical to appropriate treatment regimen selection. Bone biopsies establish the safety and efficacy of new therapeutic modalities. Further, new techniques such as molecular morphometry (in situ hybridization and immunohistochemistry) and analysis of bone content and crystal perfection have been applied to undecalcified bone and elucidated pathogenetic mechanisms or abnormalities in bone microstructure. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：146 / 152

页数：6

共 31 条

[1]

Meunier P., Courpron P., Edouard C., Et al., Physiological senile involution and pathological rarefaction of bone. Quantitative and comparative histological data, Clin Endocrinol Metab, 2, pp. 239-256, (1973)

[2]

Dorr L.D., Arnala I., Faugere M.C., Et al., Five-year postoperative results of cemented femoral arthroplasty in patients with systemic bone disease, Clin Orthop Relat Res, 259, pp. 114-121, (1990)

[3]

Dorr L.D., Faugere M.C., Mackel A.M., Et al., Structural and cellular assessment of bone quality of proximal femur, Bone, 14, pp. 231-242, (1993)

[4]

Malluche H.H., Meyer W., Sherman D., Et al., Quantitative bone histology in 84 normal American subjects. Micromorphometric analysis and evaluation of variance in iliac bone, Calcif Tissue Int, 34, pp. 449-455, (1982)

[5]

Malluche H.H., Faugere M.C., Atlas of Mineralized Bone Histology, (1986)

[6]

Duncan H., Rao S., Parfitt A.M., Complications of bone biopsy, Bone Histomorphometry, pp. 483-486, (1981)

[7]

Johnson K.A., Kelly P.J., Jowsey J., Percutaneous biopsy of the iliac crest, Clin Orthop Relat Res, 123, pp. 34-36, (1977)

[8]

Parfitt A., Stereologic basis of bone histomorphometry

[9]

theory of quantitative microscopy and reconstruction of the third dimension, Bone Histomorphometry: Techniques and Interpretation, pp. 53-87, (1983)

[10]

Meunier P., Bone histomorphometry, Osteoporosis: Etiology, Diagnosis, and Management, pp. 299-318, (1995)

← 1 2 3 4 →