Evolving medical therapies for ulcerative colitis.

被引：11
作者：
Cohen R.D. [1 ]
机构：
[1] Department of Medicine, University of Chicago Medical Center, Section of Gastroenterology, 5841 South Maryland Avenue, Chicago, 60637, IL
来源：
Current Gastroenterology Reports | 2002年 / 4卷 / 6期
关键词：
Ulcerative Colitis; Infliximab; Budesonide; Mesalazine; Ulcerative Colitis Patient;
D O I：
10.1007/s11894-002-0026-y
中图分类号：
学科分类号：
摘要：
Therapies for patients with ulcerative colitis have, until recently, been limited in scope and efficacy. New formulations of mesalamine and corticosteroids have challenged the older therapies with respect to both efficacy and safety. The application of 6-mercaptopurine and azathioprine for steroid-refractory disease and maintenance of remission has resulted in studies of other candidate immunomodulatory agents. Biologic therapies targeting tumor necrosis factor, adhesion molecules, or other cytokines are under intense scrutiny as potential disease-altering agents that may even replace currently available products. Other approaches, including such wide-ranging products as heparin, nicotine, and probiotics, suggest that control of ulcerative colitis may require an individualized approach for each patient.
引用
收藏
页码：497 / 505
页数：8
相关论文
共 243 条
[71]  
Nolen H III(2002)Octreotide in patients with active ulcerative colitis treated with high dose corticosteroids (OPUS 1) Aliment Pharmacol Ther 16 1131-1135
[72]  
Fedorak RN(2002)A double-blind, randomized, placebo-controlled trial of essential fatty acid supplementation in the maintenance of remission of ulcerative colitis Scand J Gastroenterol 37 444-449
[73]  
Friend DR(1999)Wheat grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial Lancet 354 635-639
[74]  
Rizzello F(2000)Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial Gastroenterology 119 305-309
[75]  
Gionchetti P(2002)Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial Am J Gastroenterol 97 382-388
[76]  
D’Arienzo A(1999)Complementary medicine use in children and young adults with inflammatory bowel disease J Tradit Chin Med 19 111-114
[77]  
Sood A(1999)Observation of the efficacy of acupuncture and moxibustion in 62 cases of chronic colitis J Tradit Chin Med 19 163-165
[78]  
Midha V(2002)Clinical study on 118 cases of ulcerative colitis treated by integration of traditional Chinese and Western medicine Aliment Pharmacol Ther 16 197-205
[79]  
Sood N(2002)Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study Aliment Pharmacol Ther 16 87-99
[80]  
Mahadevan U(2001)Efficacy and safety of oral ridogrel in the treatment of ulcerative colitis: two multicentre, randomized, double-blind studies Eur J Gastroenterol Hepatol 13 397-400
3456789101112