Genetic basis of human testicular germ cell cancer: insights from the fruitfly and mouse

被引：0
作者：
Catherine M. Browne
Gary R. Hime
Peter Koopman
Kate L. Loveland
机构：
[1] University of Queensland,Institute for Molecular Bioscience, Queensland Bioscience Precinct
[2] Australian Research Council Centre of Excellence in Biotechnology and Development,Department of Anatomy and Cell Biology
[3] University of Melbourne,undefined
[4] Monash Institute of Medical Research,undefined
来源：
Cell and Tissue Research | 2005年 / 322卷
关键词：
Carcinoma in situ; Teratoma; Seminoma; Embryonal carcinoma; Choriocarcinoma; Yolk sac tumour; Embryonal stem cells; Mouse models; models; Human;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The prevalence of tumours of the germ line is increasing in the male population. This complex disease has a complex aetiology. We examine the contribution of genetic mutations to the development of germ line tumours in this review. In particular, we concentrate on fly and mouse experimental systems in order to demonstrate that mutations in some conserved genes cause pathologies typical of certain human germ cell tumours, whereas other mutations elicit phenotypes that are unique to the experimental model. Despite these experimental systems being imperfect, we show that they are useful models of human testicular germ cell tumourigenesis.
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页码：5 / 19
页数：14
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