Long-term complications after visceral transplantation

被引:2
作者
Darstein, F. [1 ]
Zimmermann, T. [1 ]
Lang, H. [2 ]
机构
[1] Univ Med Mainz, Interdisziplinares Transplantat Zentrum, Med Klin & Poliklin 1, Gastroenterol & Hepatol, Langenbeck Str 1, D-55131 Mainz, Germany
[2] Univ Med Mainz, Allgemein Viszeral & Transplantat Chirurg, Mainz, Germany
来源
GASTROENTEROLOGE | 2019年 / 14卷 / 04期
关键词
Liver transplantation; Postoperative complications; Survival rate; Immunosuppression; Graft rejection; DE-NOVO MALIGNANCY; LIVER-TRANSPLANTATION; RISK-FACTORS; PRACTICE GUIDELINE; RECIPIENTS; MANAGEMENT; TACROLIMUS; ORGAN; MORTALITY; EVOLUTION;
D O I
10.1007/s11377-019-0360-3
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The impact of long-term complications after visceral transplantation is increasing due to organ shortage and improved survival. This article provides an overview of the literature, guidelines and expert opinions. Recurrence of the underlying disease, infections, malignancy and cardiovascular events are the main reasons for long-term mortality after visceral transplantation. Diabetes mellitus, arterial hypertension, obesity and hyperlipidemia are diagnosed more frequently compared to the general population. Furthermore, rejection episodes must be considered. Adequate evaluation before transplantation as well as intensive postoperative follow-up with screening for long-term complications and their therapy is necessary to optimize long-term survival after visceral transplantation.
引用
收藏
页码:296 / 300
页数:5
相关论文
共 31 条
[1]   Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR) [J].
Adam, Rene ;
Karam, Vincent ;
Delvart, Valerie ;
O'Grady, John ;
Mirza, Darius ;
Klempnauer, Jurgen ;
Castaing, Denis ;
Neuhaus, Peter ;
Jamieson, Neville ;
Salizzoni, Mauro ;
Pollard, Stephen ;
Lerut, Jan ;
Paul, Andreas ;
Carlos Garcia-Valdecasas, Juan ;
Juan Rodriguez, Fernando San ;
Burroughs, Andrew .
JOURNAL OF HEPATOLOGY, 2012, 57 (03) :675-688
[2]   Incidence and risk factors for diabetes, hypertension and obesity after liver transplantation [J].
Anastacio, Lucilene Rezende ;
Ribeiro, Helem de Sena ;
Ferreira, Livia Garcia ;
Lima, Agnaldo Soares ;
Vilela, Eduardo Garcia ;
Toulson Davisson Correia, Maria Isabel .
NUTRICION HOSPITALARIA, 2013, 28 (03) :643-648
[3]  
[Anonymous], 2017, JAHRESBERICHT DSODSO
[4]   Biomarkers of Over-Immunosuppression [J].
Budde, K. ;
Matz, M. ;
Duerr, M. ;
Glander, P. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 90 (02) :316-322
[5]   Risk factors and incidence of de novo malignancy in liver transplant recipients: a systematic review [J].
Chak, Eric ;
Saab, Sammy .
LIVER INTERNATIONAL, 2010, 30 (09) :1247-1258
[6]   Comparison of the Incidence of Malignancy in Recipients of Different Types of Organ: A UK Registry Audit [J].
Collett, D. ;
Mumford, L. ;
Banner, N. R. ;
Neuberger, J. ;
Watson, C. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 (08) :1889-1896
[7]   2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejectio [J].
Demetris, A. J. ;
Bellamy, C. ;
Hubscher, S. G. ;
O'Leary, J. ;
Randhawa, P. S. ;
Feng, S. ;
Neil, D. ;
Colvin, R. B. ;
McCaughan, G. ;
Fung, J. J. ;
Del Bello, A. ;
Reinholt, F. P. ;
Haga, H. ;
Adeyi, O. ;
Czaja, A. J. ;
Schiano, T. ;
Fiel, M. I. ;
Smith, M. L. ;
Sebagh, M. ;
Tanigawa, R. Y. ;
Yilmaz, F. ;
Alexander, G. ;
Baiocchi, L. ;
Balasubramanian, M. ;
Batal, I. ;
Bhan, A. K. ;
Bucuvalas, J. ;
Cerski, C. T. S. ;
Charlotte, F. ;
de Vera, M. E. ;
ElMonayeri, M. ;
Fontes, P. ;
Furth, E. E. ;
Gouw, A. S. H. ;
Hafezi-Bakhtiari, S. ;
Hart, J. ;
Honsova, E. ;
Ismail, W. ;
Itoh, T. ;
Jhala, N. C. ;
Khettry, U. ;
Klintmalm, G. B. ;
Knechtle, S. ;
Koshiba, T. ;
Kozlowski, T. ;
Lassman, C. R. ;
Lerut, J. ;
Levitsky, J. ;
Licini, L. ;
Liotta, R. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (10) :2816-2835
[8]   Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study [J].
Fischer, Lutz ;
Saliba, Faouzi ;
Kaiser, Gernot M. ;
De Carlis, Luciano ;
Metselaar, Herold J. ;
De Simone, Paolo ;
Duvoux, Christophe ;
Nevens, Frederik ;
Fung, John J. ;
Dong, Gaohong ;
Rauer, Barbara ;
Junge, Guido .
TRANSPLANTATION, 2015, 99 (07) :1455-1462
[9]   Opportunistic Infections-Coming to the Limits of Immunosuppression? [J].
Fishman, Jay A. .
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2013, 3 (10)
[10]   Cardiovascular disease after liver transplantation: When, What, and Who Is at Risk [J].
Fussner, Lynn A. ;
Heimbach, Julie K. ;
Fan, Chun ;
Dierkhising, Ross ;
Coss, Elizabeth ;
Leise, Michael D. ;
Watt, Kymberly D. .
LIVER TRANSPLANTATION, 2015, 21 (07) :889-896