Association of the PTPN22 polymorphism C1858T with type 1 diabetes mellitus

被引：0
作者：
E. Yu. Lavrikova
A. G. Nikitin
Yu. A. Seregin
L. I. Zilberman
N. M. Tsitlidze
T. L. Kuraeva
V. A. Peterkova
I. I. Dedov
V. V. Nosikov
机构：
[1] State Research Center GosNIIgenetika,
[2] Endocrinology Research Center,undefined
来源：
Molecular Biology | 2009年 / 43卷
关键词：
type 1 diabetes mellitus; polymorphism ; association; family-based test;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
PTPN22 encodes a lymphoid protein tyrosine phosphatase LYP. Association of the PTPN22 polymorphism C1858T with type 1 diabetes mellitus was investigated using the transmission disequilibrium test (TDT) and a comparative analysis of the allele and genotype frequency distributions. The study involved two groups of families from Russian populations of Moscow and Samara with concordantly (27 families) and discordantly (62 families) affected sibs, as well as groups of type 1 diabetes patients and healthy individuals. The association of the PTPN22 polymorphism with type 1 diabetes was not significant by TDT analysis, but was significant by comparison of the allele and genotype frequency distributions. Thus, a case-control analysis detected an association of the PTPN22 polymorphism C1858T with type 1 diabetes mellitus in Russians.
引用
收藏
页码：968 / 971
页数：3
相关论文
共 81 条
  • [1] Chistiakov D.A.(2001) gene polymorphisms are associated with, and linked to, insulin-dependent diabetes mellitus in a Russian population BMC Genet. 2 6-86
  • [2] Savost’anov K.V.(1994)Frequency analysis of Acta Diabetol. 31 82-779
  • [3] Nosikov V.V.(2005) and Am. J. Hum. Genet. 76 773-864
  • [4] Gavrilov D.K.(2007) gene alleles and susceptibility to type 1 diabetes mellitus in Russian patients Nature Genet. 39 857-619
  • [5] Kuraeva T.L.(2006)Localization of a type 1 diabetes locus in the Nature Genet. 38 617-338
  • [6] Dedov I.I.(2004) region by use of tag single-nucleotide polymorphisms Nature Genet. 36 337-56
  • [7] Vella A.(2007)Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes Rheumatology (Oxford). 46 49-223
  • [8] Cooper J.D.(2006)A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferoninduced helicase (IFIH1) region Semin. Immunol. 18 214-571
  • [9] Lowe C.E.(2005)A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes Am. J. Hum. Genet. 76 561-526
  • [10] Todd J.A.(2007)The Diabetes. 56 522-2024
123456789