Hypothalamic-pituitary-adrenal system and enzymes of the glutathione-dependent antioxidant system during stress and aging

被引：0
|
作者：
N. D. Goncharova
A. V. Shmaliy
V. Yu. Marenin
S. A. Smelkova
机构：
[1] Russian Academy of Medical Sciences,Laboratory of Endocrinology, Institute of Medical Primatology
[2] Sochi State University of Tourism and Health Resort Business,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2007年 / 144卷
关键词：
glutathione reductase; corticosteroids; acute psychoemotional stress; aging; monkeys;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Activity of glutathione-dependent antioxidant enzymes (glutathione peroxidase, glutathione reductase, and glutathione transferase) in blood erythrocytes from female Macaca mulatta (6–8 and 20–26 years) was measured during activation of the hypothalamic-pituitary-adrenal system under conditions of acute psychoemotional stress (2-h restraint stress). Glutathione reductase activity increased during stress, depended on the time of day, and strongly correlated with blood corticosteroid level. Circadian variations in stress reactivity of glutathione reductase during aging were accompanied by similar changes in stress reactivity of the hypothalamic-pituitary-adrenal system.
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页码：730 / 733
页数：3
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