Striatal FP-CIT uptake differs in the subtypes of early Parkinson’s disease

被引:0
作者
J. Spiegel
D. Hellwig
S. Samnick
W. Jost
M.-O. Möllers
K. Fassbender
C.-M. Kirsch
U. Dillmann
机构
[1] Saarland University,Department of Neurology
[2] Saarland University,Department of Nuclear Medicine
[3] Deutsche Klinik fur Diagnostik,Department of Neurology
来源
Journal of Neural Transmission | 2007年 / 114卷
关键词
Keywords: Parkinson’s disease, FP-CIT SPECT;
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摘要
In idiopathic Parkinson’s disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.
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页码:331 / 335
页数:4
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