Regulation of V2 receptor by vasopressin is different in Brattleboro rats compared with Wistar

被引：0
作者：
L. E. Katkova
G. S. Baturina
E. I. Solenov
L. N. Ivanova
机构：
[1] Russian Academy of Sciences,Institute of Cytology and Genetics, Siberian Branch
[2] Novosibirsk State University,undefined
来源：
Doklady Biochemistry and Biophysics | 2015年 / 463卷
关键词：
Vasopressin; Cytosolic Fraction; Principal Cell; dDAVP; DOKLADY Biochemistry;
D O I：
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学科分类号：
摘要：
This paper presents the new priority data on the effect of genetically determined deficiency of endogenous vasopressin on the functioning of V2 receptor in the plasma membrane of the principal cells of the collection ducts of Brattleboro rats. It was found that 2-day desmopressin administration results in the activation of V2 receptor gene expression in Brattleboro rat, whereas in Wistar rats the content of mRNA did not change. In addition, short-term exposure of the collection ducts of the kidneys to the hormone led to V2 receptor internalization from the plasma membrane in Wistar rats, but had no effect on the protein content in Brattleboro rats.
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页码：247 / 250
页数：3
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