A Phase II study of celecoxib, gemcitabine, and cisplatin in advanced pancreatic cancer

被引：0
作者：
Basil F. El-Rayes
Mark M. Zalupski
Anthony F. Shields
Ann Marie Ferris
Ulka Vaishampayan
Lance K. Heilbrun
Raghu Venkatramanamoorthy
Volkan Adsay
Philip A. Philip
机构：
[1] Wayne State University,Karmanos Cancer Institute
[2] University of Michigan,undefined
来源：
Investigational New Drugs | 2005年 / 23卷
关键词：
pancreatic cancer; cisplatin; celecoxib; gemcitabine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background. Pancreatic cancer is amongst the most chemoresistant malignancies. Expression of the cyclooxygenase-2 (COX-2) enzyme plays a major role in tumor progression and resistance to therapy. A Phase II study was undertaken to determine the effect of gemcitabine by fixed-dose rate infusion (FDR), cisplatin and the COX-2 inhibitor, celecoxib, on the 6-month survival rate in patients with metastatic pancreatic cancer.
引用
收藏
页码：583 / 590
页数：7
相关论文
共 145 条
[1]  
Jemal A(2004)American Cancer Society: Cancer statistics, 2004 CA Cancer J Clin 54 8-29
[2]  
Tiwari RC(2003)Developments in the systemic therapy of pancreatic cancer Cancer Invest 21 73-86
[3]  
Murray T(2001)Prostaglandins and leukotrienes: Advances in eicosanoid biology Science 294 1871-1875
[4]  
Ghafoor A(2003)Lipoxygenase and cyclooxygenase metabolism: New insights in treatment and chemoprevention of pancreatic cancer Mol Cancer 2 10-452
[5]  
Samuels A(2001)Expression of inflammatory modulator COX-2 in pancreatic ductal adenocarcinoma and its relationship to pathologic and clinical parameters Am J Clin Oncol 24 447-146
[6]  
Ward E(2000)Cyclooxygenase-2 expression in human pancreatic adenocarcinomas Carcinogenesis 21 139-18081
[7]  
Feuer EJ(2001)Prostaglandin E2 increases growth and motility of colorectal carcinoma cells J Biol Chem 276 18075-27
[8]  
Thun MJ(2000)The contributions of cyclooxygenase-2 to tumor angiogenesis Cancer Metastasis Rev 19 19-734
[9]  
El-Rayes BF(2003)Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways Cancer Res 63 728-2675
[10]  
Shields AF(2001)K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1 Cancer Res 61 2670-4362
12345678910