Role of vertically transmitted viral and bacterial endosymbionts of Aedes mosquitoes. Does Paratransgenesis influence vector-borne disease control?

Mosquitoes stand as a growing menace to millions of people globally as they are effectual vectors of sundry pathogens. The resurgence of mosquito-borne diseases across the world shows that the prevailing mosquito control measures are inadequate to limit the risk of those diseases properly. Aedes species, particularly Aedes aegypti and Aedes albopictus, are the vectors of arboviruses such as Dengue, Chikungunya, and Zika. Apart from being the vectors of viruses, mosquitoes host various bacterial species and indulge in symbiotic interactions with them. Several studies have revealed the significant potentialities of gut bacteria in controlling mosquitoes. A remarkably new initiative called the paratransgenesis approach plays a vital role in this area of academics. In this study, infectious arboviruses and bacterial endosymbionts of Ae. aegypti and Ae. albopictus that can endure vertical transmission have been reviewed for comprehending the role in mosquito control. This review can unravel the major vertically transmitted arboviruses and bacterial species in Aedes mosquitoes, by divulging new strategies for mosquito control.